Daily Med Bites - 28/04/2025

Dear reader, here are the summaries of some of the latest papers from PubMed.
As you can see, I made a slight change in the format of this newsletter, trying to group as many article as possible under a single title, to allow you to skim faster on the topics of interest.
Let me know what you think about this change in the poll at the end!

Virtual Reality Rehabilitation and Tele Rehabilitation: Eye-tracking technology customizes augmented visual feedback in VR to enhance therapy outcomes. VR-based systems like ArmVR improve motor function and cognitive abilities, while virtual reality shows promise in managing pain and improving daily living activities for stroke survivors and musculoskeletal disorder patients. Additionally, VR alleviates HCI fatigue compared to flat video, increasing brain activity during recovery. VR-based systems significantly aid in motor function recovery and cognitive improvement for stroke patients, with personalized designs optimizing outcomes. Effective for improving activities of daily living and quality of life, VR also manages pain in musculoskeletal disorders and enhances upper extremity recovery compared to conventional therapy. Eye-tracking technology customizes augmented visual feedback to optimize patient engagement. Serious games and telerehabilitation are effective when personalized. Home-based rehabilitation with robots is feasible during pandemics. VR alleviates HCI fatigue through increased brain activity. Telehealth exercise interventions improve balance, motor function, walking ability, and ADLs in stroke patients. A novel tele-rehabilitation system (Tele BCI-FES) integrates BCI and FES for upper limb recovery at home. Optimal timing of rehabilitation may vary by time of day to enhance outcomes. Source 1 Source 2 Source 3 Source 4 Source 5 Source 6 Source 7 Source 8 Source 9 Source 10 Source 11 Source 12 Source 13 Source 14 Source 15

Ischemic Stroke: Shuanglu tongnao formula (SLTNF) may reverse pro-inflammatory microenvironment in treating ischemic stroke. CT16 shows promising antiplatelet and neuroprotective effects compared to edaravone. 2-Iminobiotin demonstrates safety and potential neuroprotective benefits in patients undergoing endovascular thrombectomy. Ketogenic diet exerts neuroprotection by stabilizing HIF-1α, reducing inflammation and oxidative stress. Comprehensive transcriptomics data reveal critical molecular mechanisms including inflammation and mitochondrial dysregulation as therapeutic targets. Source 1 Source 2 Source 3 Source 4 Source 5

Cardiovascular Health Technology and Research: A machine learning model for early detection of cardiac valve calcification improves screening for dialysis patients. Flexible bio-integrated sensors offer real-time cardiovascular monitoring, enhancing hemodynamic assessment and prevention. Physical function is a key factor in hospitalization risk for pre-dialysis CKD patients. Source 1 Source 2 Source 3 Source 4

Heart Disease: MAIT cells protect against atherosclerosis by maintaining immune homeostasis. Immune cells have dual roles in myocardial infarction with potential for immunomodulatory treatments. CCDC80 downregulation in vascular smooth muscle cells is linked to aortic dissection, indicating its protective role. Alternative polyadenylation regulates the monocyte-to-macrophage transition during atherosclerosis, offering insights into plaque formation mechanisms. Source 1 Source 2 Source 3 Source 4

Antibiotic Resistance: ARGs identified in wastewater from Sabadell, Spain, with macrolides-lincosamides-class B streptogramins prevalent. A novel multiplex fluorescent PCR assay detects aminoglycoside resistance genes efficiently. Environmental pathways for antibiotic resistance spread need further study in Canada. Tn-Seq identifies new genetic targets to combat β-lactam resistant bacteria. Source 1 Source 2 Source 3 Source 4

That’s enough for today, see you tomorrow!

As always, these extremely reduced summaries may be incomplete or inexact in some aspects. Make sure to always read the papers of interest.

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