Daily Med Bites 05/05/2025

Dear reader, here are the summaries of some of the latest papers from PubMed.

Photothermal Therapy:

• Source: This paper’s key contribution is the development of a biosafe photothermal therapy strategy using ultrasmall renal-clearable gold nanoparticles that selectively accumulate in liver tumors, enabling precise PTT and chemotherapy without damaging surrounding normal tissue.

• Source: Gold shell-isolated nanoparticles (AuSHINs) show high photothermal therapy efficacy for cancer treatment due to their excellent photoconversion efficiency and biocompatibility.

• Source: This study demonstrates that combining photothermal therapy and metalloimmunotherapy using Co + diABZI@J-dICG nanoparticles effectively treats HCC by enhancing both PTT efficacy and innate immune response activation.

• Source: This paper introduces a NIR-II laser-responsive nanocapsule (P/A@G@H) that combines CO-assisted photothermal therapy and thermodynamic therapy to enhance tumor treatment efficacy while mitigating heat shock protein expression.

• Source: A smart dual-loaded nanoplatform using ZIF-8 enhances radiotherapy sensitivity and photothermal therapy, reshaping the tumor microenvironment to inhibit tumor growth effectively in a xenograft model.

• Source: The study demonstrates that upconversion nanoparticles (UCNPs) encapsulating a photosensitizer can effectively treat psoriasis when activated by near-infrared light, offering a promising new photodynamic therapy approach with improved tissue penetration.

3D Bioprinting:

• Source: The paper’s main contribution is the development of a 3D bioprinting technique to create high-resolution, internally perfusable scaffolds that can be integrated with vascular and perfusion systems to form advanced tissue engineering platforms, improving cell viability and functionality.

• Source: DLP-based 3D bioprinting of GelMA/PEGDA hydrogels can create complex vascular structures that enhance tissue infiltration and vascularization, offering a promising platform for engineered organ transplantation.

• Source: 3D-printed scaffolds show promise for cranial bone regeneration due to their patient-specific design and material properties, but further research is needed to optimize mechanical performance and facilitate clinical translation.

• Source: Physical properties of 3D scaffolds, including size-scale dimensions and orientation at different scales, significantly influence macrophage polarization towards a tissue-regenerative phenotype, highlighting the importance of scaffold design in enhancing tissue regeneration.

• Source: 3D-printed, patient-specific implants and models improve surgical accuracy, efficiency, and outcomes in complex pelvic surgeries.

• Source: This study successfully created a 3D bioprinted vascularized tri-culture model that closely mimics human airways, addressing gaps in existing In Vitro models by including pulmonary vasculature and demonstrating its relevance for studying chronic lung diseases.

• Source: This paper’s main contribution is the use of two-photon lithography to create bioactive glass scaffolds with micron-scale features, enabling precise control over scaffold design and enhancing cell behavior for tissue engineering applications.

• Source: This study demonstrates the successful fabrication of a biodegradable 3D neural scaffold with enhanced mechanical and electrical properties using PVA, Fe₃O₄ NPs, and PPy, showing potential for nerve tissue regeneration.

• Source: PRP-loaded scaffolds enhance sustained delivery of growth factors, improving regenerative medicine outcomes in tissue repair and engineering applications.

That’s enough for today, see you tomorrow!

As always, these extremely reduced summaries may be incomplete or inexact in some aspects. Make sure to always read the papers of interest.

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